REPOSITIONING OF ANTIARRHYTHMICS FOR PROSTATE CANCER TREATMENT: A NOVEL STRATEGY TO REPROGRAM CANCER-ASSOCIATED FIBROBLASTS TOWARDS A TUMOR-SUPPRESSIVE PHENOTYPE

Abstract Background Cancer-associated fibroblasts (CAFs) play a significant role in fueling prostate cancer (PCa) progression by interacting with tumor cells.A previous gene expression analysis revealed that CAFs up-regulate genes coding for voltage-gated cation channels, as compared to normal prostate fibroblasts (NPFs).In this study, we explored

Normal baby lock spirit embroidery machine price cellular function relies on the efficient and accurate readout of the genetic code.Single-molecule experiments show that transcription and replication are highly intermittent processes that are frequently interrupted by polymerases pausing and reversing directions.Although intermittent dynamics in re

Background: The elderly, especially those who reside in institutions and have a minority or low-income background, often have unmet oral health needs.As life expectancy increases, so will the need for oral health providers skilled in addressing the unique challenges presented by geriatric patients.Methods: Dentists for Della is a student organizati

Microsurgery, a pivotal surgical field that changed medical perspectives in the 20th century, presents numerous technical challenges due to the precision it requires from the surgeon.To acquire the requisite skills, comprehensive training is imperative.Initiation into microsurgical training on experimental bushranger awning models is a prerequisite